The authors also seem to selectively show the positive or negative error bars in the figures.Ĥ) For the hair cell counts, it's not clear what PFF groups are being compared to. This raises question about the statistical test result being reported. From the graphs in figure 3, it looks like the error bars are overlapping. Given that the animals were exposed to broadband noise, why was pure tone ABR performed only at 2 frequencies?ģ) The authors report statistical significant difference in the ABR thresholds for the high PFF-A group on day 1. The bandwidth used has not been mentioned. At this level, in this strain, days 1-3 are likely to be CTS rather than TTS.Ģ) The noise exposure was broadband white noise. In this study, the authors have used 115dB SPL noise for 2 hours to study TTS. duration will produce a TTS in the C57BL/6 strain. They are listed below.ġ) Studies from other labs (Ohlemiller, Hirose, Kaur, Liberman etc.) have demonstrated that 112dB SPL or higher intensity of noise for 2 hrs. While the study is interesting, there are multiple concerns that question the conclusions of the study. reports the potential otoprotective effect of two polyphenols extracted from a brown algae. Line 364 - Ecklonia stolonifera (in italics) Line 359 - Ecklonia stolonifera (in italics) > I inserted a space between number 10 and "mg/kg". > I inserted a space between "18-20" and "g". Line 177 - Briefly, the whole plant of Ecklonia cava (Ochrophyta, Phaeophyceae) was collected off the coast of Jeju Island, > Due to changes in the manuscript, currently the word is in line 62. > Due to changes in the manuscript, currently the word is in line 59. > Due to changes in the manuscript, currently the word is in line 55.
> Due to changes in the manuscript, currently the word is in line 54. > Due to changes in the manuscript, currently the word is in line 16/17. Line 364 - Ecklonia stolonifera (in italics) Line 359 - Ecklonia stolonifera (in italics) Line 177 - Briefly, the whole plant of Ecklonia cava (Ochrophyta, Phaeophyceae) was collected off the coast of Jeju Island, The manuscript entitled "Effect of Phlorofucofuroeckol A and Dieckol Extracted from Ecklonia Cava on Noise-induced Hearing Loss in a Mouse Model" addresses a relevant and under-published topic, so I am of the opinion that it should be accepted for publication after the introduction of corrections.